Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children
Identifieur interne : 002677 ( Main/Exploration ); précédent : 002676; suivant : 002678Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children
Auteurs : Peter F. Wright [États-Unis] ; Nobuhiko Okabe [États-Unis] ; Kelly T. Mckee [États-Unis] ; H. F. Maassab [États-Unis] ; David T. Karzon [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1982.
Abstract
Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.
Url:
DOI: 10.1093/infdis/146.1.71
Affiliations:
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Wright</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Okabe, Nobuhiko" sort="Okabe, Nobuhiko" uniqKey="Okabe N" first="Nobuhiko" last="Okabe">Nobuhiko Okabe</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Mckee, Kelly T" sort="Mckee, Kelly T" uniqKey="Mckee K" first="Kelly T." last="Mckee">Kelly T. Mckee</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Karzon, David T" sort="Karzon, David T" uniqKey="Karzon D" first="David T." last="Karzon">David T. Karzon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1982-07">1982</date><biblScope unit="vol">146</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="71">71</biblScope><biblScope unit="page" to="79">79</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></region><name sortKey="Karzon, David T" sort="Karzon, David T" uniqKey="Karzon D" first="David T." last="Karzon">David T. Karzon</name><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><name sortKey="Mckee, Kelly T" sort="Mckee, Kelly T" uniqKey="Mckee K" first="Kelly T." last="Mckee">Kelly T. Mckee</name><name sortKey="Okabe, Nobuhiko" sort="Okabe, Nobuhiko" uniqKey="Okabe N" first="Nobuhiko" last="Okabe">Nobuhiko Okabe</name><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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